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apalutamide will minimize the level or influence of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with medicines that happen to be CYP2C19 substrates may result in reduce exposure to those medications.Effect of coadministration of a dual CYP